Exosomal miRNAs suppressed cell proliferation by downregulating the C-X-C motif chemokine ligand 12 (CXCL12); exosomal-miR-23b augmented cell quiescence by inhibiting myristoylated alanine-rich C-kinase substrate expression in the metastatic niche [64]; miR-10b molded the TME to promote tumor metastasis [65] of breast cancer (BC) cells. This evidence concerns the gene CXCL12 and breast carcinoma.