Supporting the results above, our analysis of four other HCC cohort datasets downloaded from the Gene Expression Omnibus (GEO): GSE36376 (Park 2012, n = 433), GSE64041 (Makowska 2014, n = 120), GSE14520 (Wang 2009, n = 445), GSE76297 (Wang 2015, n = 304) showed that SAE1 was significantly overexpressed in all these four datasets (Figure 2D), further confirming the overexpression of the gene in TCGA−LIHC. Here, SAE1 is linked to hepatocellular carcinoma.