SAE1 and hepatocellular carcinoma: Having demonstrated that SAE1 is significantly more expressed in HCC compared with the non-tumor samples (~1.1-fold, p < 0.0001) (Figure 2A), to minimize probable experimental design-based bias, we excluded unpaired cases (n = 321) and analyzed the expression of SAE1 in only cases with paired tumor–non-tumor samples (n = 100).