SAE1 and hepatocellular carcinoma: Furthermore, from our intergroup analysis of SAE1 expression in HCC vs. normal liver for diagnostic implication, the area under the ROC curve (AUC) was 0.925 (Youden’s J = 0.71, SE = 0.01, p < 0.0001) (Figure 4D), with hazard ratios and 95% confidence intervals of 1.873 (1.321–2.656) and 1.809 (1.345–2.434) for OS and PFS, respectively (Figure 4E,F).