SAE1 and cancer: The upregulation of SAE1 expression was also found in several other cancer types, including lung squamous cell carcinoma (LUSC, n = 553), colon adenocarcinoma (COAD, n = 327), head and neck squamous cell carcinoma (HNSC, n = 534), kidney chromophobe (KICH, n = 91), breast invasive carcinoma (BRCA, n = 1211), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC, n = 306) and uterine corpus endometrial carcinoma (UCEC, n = 211) (Figure 1C).