GPC3 and hepatocellular carcinoma: Similarly, histochemical biomarkers of HCC including glypican-3 (GPC-3), hepatocyte paraffin 1 (Hep Par 1), heat shock protein 70 (HSP70), glutamine synthetase (GS), arginase-1 (Arg-1), cytokeratin 7 and 19 (CK7 and CK19) are also plagued with same weakness in spite of their overall strength [8,9].