The results of our gene set enrichment analysis of the LIHC (n = 371), GSE14520 (n = 225), GSE36376 (n = 240), and GSE64041 (n = 60) HCC datasets showed the existence of significant positive correlation between high SAE1 and dysregulated reactive oxygen species (ROS), glycolysis, and cholesterol homeostasis pathways in patients with HCC (Figure 6A). Here, SAE1 is linked to hepatocellular carcinoma.