The data showed that PEG-BHD1028 significantly increased glucose uptake in the insulin-resistant C2C12 myotubes in a dose-dependent manner (p ≤ 0.01) relative to untreated or insulin-only treated insulin-resistant cells (Figure 9B), implying that PEG-BHD1028 effectively ameliorates insulin resistance. Here, INS is linked to Insulin resistance.