These findings suggest that the DNA repair high HCC is associated with a high intratumor heterogeneity and high fraction of CD8+ T cells, Th1 and Th2 cells, and low fraction of regulatory T cells and M2 macrophages, but not with mutations, immune cell infiltrations, or cytolytic activity, which is perhaps the most direct measurement of anti-tumor T cell immunity and reflects the overall cancer immunity of the tumor immune microenvironment. This evidence concerns the gene CD8A and cancer.