Furthermore, DNA repair high HCC enriched the cancer aggressiveness-related gene sets, including the unfolded protein response, PI3K/AKT/MTOR signaling, Mtorc1, Notch signaling, and WNT-β catenin signaling pathways (Figure 4B; NES = 1.73 and FDR = 0.03, NES = 1.68 and FDR = 0.03, NES = 1.57 and FDR = 0.07, NES = 1.34 and FDR = 0.20, NES = 1.37 and FDR = 0.19, respectively). This evidence concerns the gene AKT1 and cancer.