CB2 activation led to ceramide-mediated bladder cancer cell apoptosis [9,10] and treatment of bladder cancer cells with CB2 agonists induced caspase 3-activation [12], adding credence to the suggestion that cannabinoids act, directly or indirectly, via the CB2 receptor in these cells to induce programmed cell death. This evidence concerns the gene CNR2 and urinary bladder carcinoma.