Indeed, infection of dendritic cells and IL-13 treated macrophages could be blocked by pre-treatment with an anti-DC-SIGN monoclonal antibody, and cell lines not normally susceptible to KSHV infection, such as K562 and B-LCL cells, were permissive to KSHV infection when transfected to overexpress DC-SIGN [50]. The gene discussed is CD209; the disease is infection.