TP53 and adenocarcinoma: Furthermore, somatic mutational index of acinar subtype is higher than adenocarcinoma being the most frequent mutations in the following genes: FAT1, FAT3, and FAT4 (57%), BRCA2 (42%), SMAD4 (26%), JAK1 (17%), RB1 (13%), TP53 (13%), CTNNB1 (11%), APC (9%), ARID1A (9%), GNAS (9%), MLL3 (9%), PTEN (9%), RNF43 (4%) and MEN1 (4%); however, KRAS mutations are not often observed in acinar subtype (Figure 3 and Table 1) [98,99].