WNK2 and hepatocellular carcinoma: Therefore, we investigated the ability of fraxetin to (1) inhibit cellular proliferation, (2) induce cell cycle arrest and apoptosis, (3) hamper mitochondrial function and calcium homeostasis, (4) regulate gene transcription, and (5) dysregulate intracellular signaling pathways, mitogen activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K), in HCC.