Notably, six genes encoding the core components of spliceosomes (PRPF31, PRPF8, PRPF3, PRPF4, PRPF6 and SNRNP200) have been linked with autosomal dominant retinitis pigmentosa (adRP), a progressive inherited retinal degeneration characterized by dysfunction and death of rod photoreceptors followed by cone photoreceptors (19,20). Here, PRPF31 is linked to autosomal dominant retinitis pigmentosa.