NPR1 and digestive system infectious disorder: Recent studies have shown that this learned aversion is contributed by detection of the metabolites of the pathogens and also by the bloating of the intestine during intestinal infection by P. aeruginosa. Intestinal infection and the subsequent bloating of the lumen trigger feedback systems that modulate the NPR-1 GPCR pathway that facilitates the regulation of aversive learning [27,28].