Furthermore, SFPQ has been associated to diverse neurological diseases, such as ALS (Thomas-Jinu et al., 2017; Luisier et al., 2018) and FTLD (Ishigaki et al., 2017), and may prove to be a critical for maintaining the circRNAome in these and other neurodegenerative pathologies. This evidence concerns the gene SFPQ and amyotrophic lateral sclerosis.