Blockade of IFNβ1 by either RNA‐interference or a blocking antibody led to an almost complete abrogation of the upregulation of anti‐viral genes in fibroblasts (Fig. 5D,E and Fig. S7C–E for siRNA silencing efficiency), whereas silencing of IFNλ1 in cancer cells had no effect (Fig. 5D,E, Fig. S7D,E for siRNA silencing efficiency). The gene discussed is IFNL1; the disease is cancer.