Antiphospholipid syndrome (APS) is defined as the occurrence of thrombotic events (thrombotic APS) and/or of recurrent pregnancy morbidity (obstetric APS), in the presence of antiphospholipid antibodies (aPLs), namely lupus anticoagulant (LA), anticardiolipin antibodies (aCL), or anti-β2 glycoprotein-I (aβ2GPI) antibodies, detected on two or more occasions at least 12 weeks apart [1]. Here, ACLY is linked to autoimmune polyendocrinopathy.