TNF and obesity due to melanocortin 4 receptor deficiency: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)],insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ±11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ±40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ±14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidativestress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF +RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ±190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38vs. HSF + RB=0.49 ± 0.16)].