To better understand the role of hepcidin in SpvB-mediated Salmonella pathogenesis and iron metabolic disorders, WT (C57BL/6 J), Hamp gene knockout (Hamp−/−) and heterozygous (Hamp+/−) mice were infected orally with either the WT or ΔspvB S. typhimurium strain. The gene discussed is HAMP; the disease is metabolic disease.