TREM-1, a cell-surface-activating receptor expressed on macrophages and monocytes in the liver, is elevated during bacterial challenge.34 TREM-1 is considered to be an important therapeutic target in several inflammatory diseases, such as severe sepsis and pneumonia35,36 A recent publication reported a new function of TREM-1 in intensifying hepatic inflammation and fibrogenesis.20 However, to the best of our knowledge, it is not completely understood if TREM-1 signaling participates in Salmonella-relevant disorders of systemic iron metabolism. This evidence concerns the gene TREM1 and Sepsis.