To better understand the role of hepcidin in SpvB-mediated Salmonella pathogenesis and iron metabolic disorders, WT (C57BL/6 J), Hamp gene knockout (Hamp−/−) and heterozygous (Hamp+/−) mice were infected orally with either the WT or ΔspvB S. typhimurium strain. Here, HAMP is linked to iron metabolism disease.