Recently, the TG2-selective and irreversible inhibitor 1–155 used in this study and developed at Aston University resulted in upto a 40% reduction in collagen deposition in a mouse Angiotensin II model of nephrosclerosis and a 60% reduction in infarct size in an acute myocardial infarction mouse model (Badarau et al. 2015; Wang et al. 2018). Here, TGM2 is linked to nephrosclerosis.