Mutations in RyR2 linked to cardiac arrhythmia, including catecholaminergic polymorphic ventricular tachycardia (CPVT), have been identified as gain of function mutations such as N4104K, R4497C, and N4895D [41, 69]. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.