2010; Deans et al. 2011). Gastric cancer incidence has become an increasing trend to Asian population, and it has shown a high mortality rate in China nowadays (Chen et al. 2013). Our preliminary study has revealed that a high mutation rate took place in MTND5 gene in gastric cancer paired clinical tissues using exome sequencing technique, indicating that the MTND5 mutation could be used as an indicator to estimate the incidence of gastric cancer. Here, MT-ND5 is linked to gastric cancer.