SOD1 and liver dysplastic nodule: To determine the mechanism of FoxO1 on ROS production in in vitro model of DN, over‐expression of FoxO1 reduced MDA levels and ROS production levels, and enhanced the levels of SOD, GSH, and GSH‐PX in in vitro model of DN, compared to the in vitro model of DN group (Figure 2a‐f).