To determine the effects of SERPINB1 on ROS production in in vitro model of DN, over‐expression of SERPINB1 reduced MDA levels and ROS production levels and enhanced the levels of SOD, GSH, and GSH‐PX in in vitro model of diabetic nephropathy, compared to the in vitro model of DN group (Figure 4a‐f). Here, SERPINB1 is linked to liver dysplastic nodule.