Fisetin in murine xenograft pancreatic cancer PANC‐1 cells inhibits PANC‐1 cell proliferation, enhances AMPK/mTOR signaling pathway and stress‐induced transcription factor p8, induces autophagy (Figure 1), and increases the ATF4 and ATF6 (Jia et al., 2019). This evidence concerns the gene ATF6 and familial pancreatic carcinoma.