Likewise, in vivo role of fisetin against lung cancer cell lines of mouse xenograft model was associated with induction of apoptosis, promotion of caspase‐3 signaling pathway, reduction in antiapoptotic proteins (Bcl‐2 and Bcl‐xl), enhancement in pro‐apoptotic proteins (Bax and Bad), and enhancement in the death receptor (DR) of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), respectively (Shi, Wang, Meng, Chen, & Meng, 2017). The gene discussed is BAD; the disease is lung cancer.