TP53 and urinary bladder cancer: The induction of bladder cancer in experimental animals (rat) was done via intravesical N‐methyl‐N‐nitrosourea (MNU), whereas administration of fisetin bioactive compound prevented from the bladder cancer cell proliferation through inducing apoptosis, down‐regulating the NF‐κB pathway activity, up‐regulating the p53 pathway activity, and exhibiting changes in the ratio of pro‐ and antiapoptotic proteins (Li, Qu, et al., 2014).