TP53 and malignant colon neoplasm: Researchers also found that fisetin in combination with geldanamycin or radicicol in vivo study in human COLO205 colon cancer cells significantly increased expressions of caspase‐3 and caspase‐9 activities, modified the Bcl‐2 but not Bax protein or Bcl‐XL, and decreased the p53 protein along with enhancement in ubiquitin‐tagged proteins, respectively (Wu, Lien, Shen, Yang, & Chen, 2013; Yu, Yang, Peng, Yu, & Chiu, 2011).