In in vitro and in vivo studies, fisetin works as an effective anticancer agent via inhibiting cell viability and tumor growth, inducing apoptosis, promoting caspase‐8 and cytochrome c expressions, and suppressing the aberrant activation of IGF1R and AKT proteins in LoVo cells of athymic nude mouse xenograft model (Jeng et al., 2018). This evidence concerns the gene AKT1 and neoplasm.