Likewise, in vivo role of fisetin against lung cancer cell lines of mouse xenograft model was associated with induction of apoptosis, promotion of caspase‐3 signaling pathway, reduction in antiapoptotic proteins (Bcl‐2 and Bcl‐xl), enhancement in pro‐apoptotic proteins (Bax and Bad), and enhancement in the death receptor (DR) of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL), respectively (Shi, Wang, Meng, Chen, & Meng, 2017). This evidence concerns the gene BCL2L1 and lung cancer.