MAPK8 and Familial prostate cancer: A peer group of researchers and investigators explored that multiple processes are involved to prevented from the proliferation of prostate cancer such as suppression of MMP‐2 and MMP‐9 activities, inhibition of phosphorylation of c‐Jun N‐terminal kinases 1 and 2 (JNK1/2) and Akt, and reduction in c‐Fos, NF‐kB, and c‐Jun, as well as showed binding abilities of NF‐kappaB and activator protein‐1 (AP‐1), respectively (Chien, Shen, Huang, Ko, & Shih, 2010).