EIF4B and neoplasm: Multiple studies found that in in vivo study, fisetin killed the THP‐1 cells in the mouse xenograft model through tumor shrinkage; suppression of the downstream components of the mTORC1 pathway; induction of hypophosphorylation of eIF4B, S6 Ri P kinase, and eEF2K; down‐regulation of levels of p70 S6 kinase; enhancement of production of NO; and elevation of Ca+2 entry activating the caspase‐dependent apoptotic pathways (Ash, Subramanian, Surolia, & Shaha, 2015; Monasterio, Urdaci, Pinchuk, Lopez‐Moratalla, & Martinez‐Irujo, 2004).