CYCS and neoplasm: In in vitro and in vivo studies, fisetin works as an effective anticancer agent via inhibiting cell viability and tumor growth, inducing apoptosis, promoting caspase‐8 and cytochrome c expressions, and suppressing the aberrant activation of IGF1R and AKT proteins in LoVo cells of athymic nude mouse xenograft model (Jeng et al., 2018).