To further our understanding of microglia phenotypic changes under inflammatory conditions, we present here preliminary data describing the microglia transcriptome after exposure to either TNF or GM-CSF, cytokines found in the multiple sclerosis demyelinating milieu (Hofman, 1989; Selmaj et al., 1991; Cannella and Raine, 1995; Vogel et al., 2015; Imitola et al., 2018). Here, TNF is linked to multiple sclerosis.