XRCC6 interacts with BAX to prevent BAX-induced apoptosis in LUAD.48 Inhibition of HSP90 functionality using small molecule inhibitor 17-allylamino-17-demethoxy-geldanamycin (17AAG) increased TβRI/II ubiquitylation and degradation, and inhibited TGFβ-induced phosphorylation and nuclear transport of endogenous SMAD2/3 in melanoma cells.38 The present study filled in the gaps of these previous reports as we elucidated that EEF1A2 regulated TGF-β/SMAD signalling and EMT through HSP90AB1. Here, HSP90AA1 is linked to melanoma.