ERCC2 and neoplasm: Alterations in DDR genes have been shown to be associated with platinum responsiveness.22,23 Five (15%) tumours harboured six alterations in DDR genes: ERCC2 (I174M and I444M), ATM (E38*, K196*, and E2904Dfs*29), BRCA2 (E23Vfs*17), and RECQL4 (X822_splice).