We also noticed expression of the TIM auto-regulatory protein family (TIMD4) and viral infection-induced auto-regulatory genes (LGALS1, LGALS3).23,24 In set 5, cell-cycle genes (CDK1, KIFs, PCNA, CCNA/B2), stress-associated genes (HSPD1, HSP90AA1, BIRC5) and chromatin remodeling-related genes (HMGB2, HMGB3, EZH2) were increased, suggesting that T-cells were largely adjusting to inflammation-driven stress (rather than mounting any discernible effector or auto-regulatory responses). Here, HMGB3 is linked to viral infectious disease.