Overall, while S+-(infected) epithelial cells reduce IFN-signaling, N+-neutrophils are characterized by increased IFN-signaling, suggesting neutrophils to be the main cell type interacting with SARS-CoV-2 viral particles and to account for the highest procurement of viral material, in line with their role as first innate immune responders to infection.49 Here, IFNA1 is linked to infection.