CD34 and Wiskott-Aldrich syndrome: In a clinical trial for Wiskott-Aldrich syndrome (WAS), IS analysis showed the frequency of CD34+ HSPCs with steady-state long term lineage reconstitutions falls between 1 in 100,000 and 1 in a 1,000,000 (a few thousand clones out of the ~80–200 million HSPCs transplanted)4.