To further elucidate the mechanism by which IL-6 induced KIAA1199, we examined the protein changes in the IL-6R signaling pathways and found that phosphatidylinositol 3-kinase (PI3K), p-Akt, and p-P65 levels in IL-6-stimulated RA FLS were significantly elevated (Fig. 6H). Here, IL6 is linked to rheumatoid arthritis.