Interestingly, the HA-degrading activity of sKIAA1199 was almost lost when the membrane fractions of KIAA1199/293T cells rather than RA FLS were added into the medium, indicating certain molecule(s) on RA FLS cell membrane may be required for sKIAA1199 involving in HA degradation. The gene discussed is CEMIP; the disease is rheumatoid arthritis.