Furthermore, several genes involved in the endocrine specification and diabetes development were significantly downregulated, such as HES1, INSM1, HNF1A, NEUROD1, NGN3, NKX2.2, GIPR, MNX1, PROX1, TCF7L2, and HHEX (Fig. 4C and Supplementary Table S4). This evidence concerns the gene NEUROG3 and diabetes mellitus.