Furthermore, several genes involved in the endocrine specification and diabetes development were significantly downregulated, such as HES1, INSM1, HNF1A, NEUROD1, NGN3, NKX2.2, GIPR, MNX1, PROX1, TCF7L2, and HHEX (Fig. 4C and Supplementary Table S4). The gene discussed is NKX2-2; the disease is diabetes mellitus.