Re-expression of WT but not KR mutant PKM2 inhibited the expression of RUNX1, but not the other core-binding factor family members RUNX2 or RUNX3 in NB4, U937 and 32DBCR-ABL leukemia cells, suggesting that SUMOylation of PKM2 is essential in modulating RUNX1 (Fig. 5C, D). This evidence concerns the gene RUNX2 and leukemia.