PKM and leukemia: Importantly, endogenous SUMOylated-PKM2 could be detected in a number of leukemia cell lines (Fig. 1D) as well as primary bone marrow mononuclear cells (BMMC) samples from acute myeloid leukemia (AML) or chronic myeloid leukemia (CML) patients (Fig. 1E) but not adherent cell lines (Fig. 1F).