On the other hand, lungs of isotype (IgG)-treated tumor-bearing and tumor-free mice under nicotine treatment were significantly infiltrated by activated neutrophils (CD11b+Ly6G+) compared to the control mice, and their proportion was remarkably reduced in lungs of anti-Ly6G treated mice (Fig. 2E; Supplementary Fig. S5A–C). Here, ITGAM is linked to neoplasm.