HERC1 and arthritic joint disease: The top-ranked genes associated with arthritis and skeletal disease in humans were Pitx1, coiled-coil domain containing 6 (Ccdc6), HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (Herc1), nebulette (Nebl), Sh3bp4, and Zfp341 (Fig. 1, Supplementary Data 7).