Combining findings from informatics prioritization with the seven lines with the most severe joint phenotypes (ClusterXN1, Pitx1, Fgfbp1, Josd1, Sh3bp4, Unk, Zfp341) identified 14 genes with strong evidence from independent sources for a functional role in osteoarthritis pathogenesis (Pitx1, Bhlhe40, Scaf11, Smg9, Col4a2, Sh3bp4, Ccdc6, Herc1, Nebl, Zfp341, ClusterXN1, Fgfbp1, Josd1, and Unk). The gene discussed is SH3BP4; the disease is osteoarthritis.