Importantly, CY similarly prevented the decline of CD3+CD4+ T cells (Genotype × Treatment: F1, 58 = 27.923, p < .001, η2p = .33, Fig. 2c) and CD3+CD8+ T cells in 3xTg-AD mice (Genotype × Treatment: F1, 58 = 7.136, p = .01, η2p = .11, Fig. 2d). Here, CD4 is linked to Alzheimer disease.