However, unlike tau, this increase in soluble human Aβ42 was greater in 3xTg-AD males than females (Genotype × Sex: F1, 68 = 8.921, p = .004, η2p = .116; 3xTg-AD males > 3xTg-AD females, t28 = 2.249, p = .033). This evidence concerns the gene MAPT and Alzheimer disease.