We observed that the proportion of CD4+ regulatory T cells (Tregs) expressing CD25 and Foxp3 was higher in both male and female 3xTg-AD mice compared to WT conspecifics (Genotype: F1, 32 = 101.511, p < .001, η2p = .76, Fig. 2e). The gene discussed is CD4; the disease is Alzheimer disease.