It is possible that CryAB aggregates activate NLRP3 or NLRP3–ASC inflammasome [NACHT, LRR, and PYD domains-containing protein 3 (NLRP3)-apoptosis-associated speck-like protein containing a CARD (ASC)], an important sensor of innate immunity, in glial cells, just like β-amyloid and tau aggregates in Alzheimer’s disease [50–52] and amyotrophic lateral sclerosis (ALS) protein in ALS [53]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.