After 8 weeks of exercise intervention, leptin (Fig. 3c) and E2 (Fig. 3d) levels were significantly decreased, whereas LH (Fig. 3a), FSH (Fig. 3b), and T (Fig. 3e) levels were significantly increased in the OME group compared with those in the OC group (Fig. 3). This evidence concerns the gene LEP and otitis media with effusion.