Furthermore, EMT inactivation inhibited proliferation, migration, invasion, and in osteosarcoma by targeting zinc finger E-box-binding protein 1 (ZEB1) through inactivation of c-Jun N-terminal kinase (JNK) and JAK1/signal transducer and activator of transcription 3 (STAT3) pathways [25]. Here, MAPK8 is linked to osteosarcoma.