Findings also have showed that miR-128 is reduced in prostate cancer, and exogenously introduced miR-128 suppresses tumor regeneration in multiple prostate cancer xenograft models by targeting the stem cell regulatory factors B cell-specific Moloney murine leukemia virus insertion site 1 (BMI-1), NANOG, and transforming growth factor beta receptor 1 (TGFBR1) [22]. This evidence concerns the gene BMI1 and Familial prostate cancer.