Rs1143643 in IL-1B increased the susceptibility to thyroid carcinoma under the allele (OR = 1.26, 95% CI 1.05–1.52, p = 0.013), genotype (OR = 1.61, 95% CI 1.10–2.34, p = 0.014), dominant (OR = 1.42, 95% CI 1.04–1.94, p = 0.027), and additive (OR = 1.27, 95% CI 1.05–1.53, p = 0.015) models. Here, IL1B is linked to thyroid gland carcinoma.