However, the use of rh-BMPs in certain orthopaedic surgeries performed in the intramedullary environment, e.g., total hip replacements involving large bone defects or intramedullary bone tumours, remains limited because more osteoclast progenitor cells are derived from hematopoietic stem cells in the bone marrow environment and rh-BMPs cannot achieve suitable osteogenesis inside of the bone marrow by promoting the differentiation of the osteoclast precursor cells, not only precursor cells which can be differentiated into osteoblast [6, 7]. This evidence concerns the gene CLN5 and bone neoplasm.