Silico analysis showed that HK1 and PKM2 in IDH1wt gliomas were significantly higher than those in IDH1mut group (P = 0.0002 and P<0.0001, respectively), while PC was significantly higher in IDH1mut than in IDH1wt gliomas (P<0.0001, Fig. 4a-c). Here, PKM is linked to central nervous system cancer.