NFKB1 and Insulin resistance: Also, PCARG plays a key role in the regulation of mitophagy (Stephenson et al. 2018) and ubiquitynylation (Loucks et al. 2016), its knockout leads to defective NFκB signaling (Meschede et al. 2020) and CHOP upregulation (Han et al. 2017), which in adipose tissue result in increased proinflammatory macrophage polarization (M1) and insulin resistance (Suzuki et al. 2017).