TMEM163 is one of the best known genes associated with obesity, LCORL was shown to associate with height, UGDH with TGFβ signaling, HLA-C with autoimmune response, HSD17B3 with fatty acids, GLRX3 with oxidative stress, RBM19 with ribosomal biogenesis, SYT4 with Ca2+ binding and pancreatic functioning, PSG5 with pregnancy development, and NTS4 with neutrophilin signaling pathway. The gene discussed is GLRX3; the disease is obesity due to melanocortin 4 receptor deficiency.