In particular,mimics of copper metalloenzymes is an importantcase, considering the essential biological role of these enzymes.24−28 Phenol oxidases (catechol oxidases, tyrosinases (TYR)), catalases,and superoxide dismutase activities are involved in many differentcellular process, and deficiency or malfunction of these activitiesis postulated to be related to the pathogenesis of many age-associateddegenerative diseases like diabetes mellitus, hypertension, anemia,vitiligo, Alzheimer’s disease, Parkinson’s disease,bipolar disorder, cancer, and schizophrenia.29−33. This evidence concerns the gene TYR and early-onset autosomal dominant Alzheimer disease.