In the MC38 subcutaneous tumor model, the proportions of CD8+ TILs in the control group, the PDT group, the BMS202 group and the combined treatment group were 12.207±2.812%, 10.287±2.369%, 10.535±2.426% and 15.712±3.619%, respectively, and the proportions of CD4+ TILs were 13.275±3.209%, 14.929±3.591%, 12.066±2.930% and 12.971±3.139%, respectively. This evidence concerns the gene CD4 and neoplasm.