Genomic analyses have identified genes with somatic single-nucleotide variations (SNVs) in PAs, e.g., Ubiquitin-specific peptidase 8 (USP8) in ACTH-PAs, G protein αs (GNAS) in GH-PAs and splicing factor 3b subunit 1 (SF3B1) in PRL-PAs [13–16]. The gene discussed is USP8; the disease is gonorrhea.