41 upregulated lncRNAs and 22 downregulated lncRNAs in somatotroph adenomas were identified (|Log2FC|>2, adjusted P value<0.001): AC126177.8, AC355974.2, LINC02475, MEG3, MEG9 and MiR7-3HG were the most significantly upregulated DEGs (Figure 2A–2E). This evidence concerns the gene MEG3 and growth hormone-secreting pituitary adenoma.