A total of 110 molecules overlapped based on DEG filter parameters (|log2FC|>2, adjusted P value<0.001), and DLK1 (somatotroph vs. lactotroph: log2FC=7.397, somatotroph vs. gonadotroph: log2FC=9.611, somatotroph vs. corticotroph: log2FC=9.832) were the most significantly different in somatotroph adenomas compared with other subtypes (Figure 1E). The gene discussed is DLK1; the disease is acromegaly.