Based on these five lncRNA expression levels and their corresponding coefficient in multivariate Cox regression analysis, a five-lncRNA signature predictive model for CCA patients prognosis was established as follows: Risk Score= (0.6542 × expression level of HULC) + (-1.2388 × expression level of AL359715.5) + (1.3769 × expression level of AC006504.8) + (-3.6697 × expression level of AC090114.2) + (-1.5165 × expression level of AP000943.4). This evidence concerns the gene HULC and cholangiocarcinoma.