The molecular epidemiological analysis revealed that p53 is mutated in almost all kinds of tumors, and approximately 5% of patients with colorectal cancer, lung cancer, melanoma, sarcoma, head and neck cancer, leukemia, esophageal cancer, ovarian cancer, testicular cancer, and cervical cancer have been found to have p53 mutations [37, 38]. Here, TP53 is linked to head and neck cancer.