Moreover, the PRC2 complex core components are conserved between Human (EZH1/2, SUZ12, EED, RBBP4/7) and Drosophila (E(z), Suz(12), Esc/EScI, Nurf55/Caf1) [40], validating this model to study the epigenetic mediated implications of this complex in cancer, including leukemia. Here, RBBP4 is linked to leukemia.