Using 98 mCRPC tumor specimens from the University of Washington rapid autopsy (UW) cohort [2] and 270 tumor specimens from the SU2C cohort [16], we confirmed through RNA-Seq that MET transcript expression is significantly upregulated in SCNPC tumors (AR-/NE+; p<0.0001) compared to AR-high metastases (AR+/NE-; Figs 1A, 1B and S1). The gene discussed is AR; the disease is neoplasm.