As treatment with 1mM NaBT for 48 h induced changes in Caco-2 cell growth and increased ALP activity, pointing to cancer cell differentiation, we decided to analyze the expression pattern of main pluripotency-associated stem cell markers to indicate the presence of putative cancer stem cells and also characterize the possible splice variants of OCT4 and NANOG which expression could be modulated by the epigenetic changes induced by NaBT. The gene discussed is POU5F1; the disease is cancer.