For example, triptolide was reported to induce autophagy and cell death in the breast cancer cell line MCF-7 through increased ERK1/2 phosphorylation [34], and cisplatin caused autophagy and cell death in mouse renal tubular epithelial cells, EpiCM-a cells, through ERK1/2 activation [35]. This evidence concerns the gene MAPK3 and breast carcinoma.