During the late phase of endotoxemia in WT mice, the TLR pathway was still affected by LPS administration in hepatic tissue (adjPval = 3.81E + 00, ratio = 23/76) as revealed by the high expression of adapter proteins mediating signal transmission, such as lipopolysaccharide binding protein (Lbp), CD14, and myeloid differentiation primary response 88 (Myd88) (Fig. 3A,B). The gene discussed is LBP; the disease is serum lipopolysaccharide activity.