TOLLIP and serum lipopolysaccharide activity: During the late phase of endotoxemia in WT mice, the TLR pathway was still affected by LPS administration in hepatic tissue (adjPval = 3.81E + 00, ratio = 23/76) as revealed by the high expression of adapter proteins mediating signal transmission, such as lipopolysaccharide binding protein (Lbp), CD14, and myeloid differentiation primary response 88 (Myd88) (Fig. 3A,B).