With the aim to elucidate the molecular processes by which cardiovascular dysfunction leads to memory impairment and increases the risk for dementia, we decided to employ a well‐established mouse model for HF in which cardiomyocyte‐specific kinase CamkIIδc is overexpressed under the control of the alpha‐MHC promoter (CamkIIδc TG mice) (Maier et al, 2003). The gene discussed is MYH6; the disease is memory impairment.