KLK3 and posterior cortical atrophy: While Mearini et al. [10] found in their prospective group of 275 men with PSA values of 2–10 ng/ml including 26 PCa patients with Gleason score ≥ 7 an AUC gain between 0.05 and 0.08 in six different models to detect significant PCa, we could not confirm this advantage.